Mesenchymal stromal/stem cell (MSC) genomic integrity

Mesenchymal stromal/stem cell (MSC) genomic integrity: New digital PCR test

In culture, human mesenchymal stromal/stem cells (hMSCs) can acquire genomic instability. These chromosome anomalies may be propagated during cell expansion, raising issues about the safety and clinical applications of such cell lines.

With the ultimate goal of maintaining in culture genetically stable hMSCs, we carried out an exhaustive meta-analysis of genomic abnormalities and referenced about 300 genetic abnormalities in hMSC lines.

We then used these data to develop the iCS-digital TM MSC test. This assay includes a set of 24 specific probes that were designed and optimized to target all human chromosomes and allows detecting, by digital PCR, more than 80% of the most frequent genetic abnormalities in hMSCs.

Thanks to its rapidity, the iCS-digital TM MSC test is a straightforward method for the routine monitoring of hMSC lines in culture.

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In this newsletter, you'll find out about the most commun genetic defect in hPSCs found on the chromosome 20q11.21. We'll explain why it is an important abnormality to detect and provide you with advice on the technologies you should be using to that effect. Read on by downloading the pdf below.

Big milestone for the team here at Stem Genomics: we have received the ISO 9001:2015 certification! This is an internationally recognised standard that ensures that our products and services meet our clients’ needs through an effective quality management system. Although it represented a rather colossal effort, everyone involved was driven by the conviction that implementing a system of continual improvement in all our processes would result in numerous benefits for our clients. This is the list of reasons that drove us to take on this journey: - Commitment to providing high-quality and consistent services to our existing and future clients - Ensure our clients’ satisfaction in relation with the efficiency of our operations: we have put futureproof processes in place to withstand the constantly changing environment we navigate in, - Show compliance with regulatory requirements and the evolving needs of our customers and their markets so we can better meet them, - Anticipate and prevent non-conformities, which we can’t afford to have with the demanding markets we address, - Remain competitive and relevant with our product and service developments operating within an established framework inspired by best business practices, - Involve and unite the team behind a shared goal. We are confident this recognised quality management system will enable our biotechnology company to provide the peace of mind our clients require when using our tests and services.

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