> Mesenchymal stromal/stem cell (MSC) genomic integrity: New digital PCR test

Mesenchymal stromal/stem cell (MSC) genomic integrity: New digital PCR test

In culture, human mesenchymal stromal cells (hMSCs) can acquire genomic instability. These chromosome anomalies may be propagated during cell expansion, raising issues about the safety and clinical applications of such cell lines.

With the ultimate goal of maintaining in culture genetically stable hMSCs, we carried out an exhaustive meta-analysis of genomic abnormalities and referenced about 300 genetic abnormalities in hMSC lines.

We then used these data to develop the iCS-digital™ MSC test. This assay includes a set of 24 specific probes that were designed and optimized to target all human chromosomes and allows detecting, by digital PCR, more than 80% of the most frequent genetic abnormalities in hMSCs.

Thanks to its rapidity, the iCS-digital™ MSC test is a straightforward method for the routine monitoring of hMSC lines in culture.

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Upcoming webinar

Join us LIVE for our webinar “Genomic stability made easy” to discover how Stem Genomics has turned cutting-edge technologies into easy testing solutions accessible to most labs.

Get expert opinions and user perspectives on our genomic stability assays in the context of iPSC research.

Happening on Tuesday, November 14, 6 pm CET

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