The iCS-digital test now published  in Stem Cell Reports

The iCS-digital TM test now published in Stem Cell Reports

Recurrent Genetic Abnormalities in Human Pluripotent Stem Cells: Definition and Routine Detection in Culture Supernatant by Targeted Droplet Digital PCR

In the article published in Stem Cell Reports in January 2020, Assou et al. demonstrate the interest of the iCS-digital TM test for routine human pluripotent stem cell (hPSC) screening. Thanks to the specificity of the digital PCR (dPCR) probe panel, the simplicity of sample collection, and the accuracy of the ddPCR technology, this test allows the fast and straightforward monitoring of hPSC integrity.

This innovative test can change how hPSC quality controls are implemented for basic research and cell therapy by increasing the test frequency to secure cell productions and avoid expensive and time-consuming cell cultures.

The iCS-digital TM test is exclusively provided by Stem Genomics as a full service.
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Digital PCR-based assay: an answer to chromosomal abnormality

Digital PCR, also known as dPCR, was first described by Sykes et al. in 1992 (Sykes et al., n.d.), and although it has been around for a while, it is not as widely practiced as qPCR worldwide. Qualified as a “robust technique”, those who have made the switch appreciate the precision and sensitivity it offers. Particularly relevant for certain fields, it has emerged as a reliable technique for quantifying target sequences and identifying rare variants. It was therefore a logical choice for Stem Genomics’ founders back in 2018.

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