The iCS-digital TM test is a straightforward method for screening human pluripotent stem cell (hPSC) clones after CRISPR gene editing

The iCS-digital TM test is a straightforward method for screening human pluripotent stem cell (hPSC) clones after CRISPR gene editing

The iCS-digital TM test offers fast and reliable detection of the most common genomic abnormalities in CRISPR/Cas9-edited hPSCs

By combining human pluripotent stem cells (hPSCs) and the CRISPR/Cas9 genome editing technology, new opportunities are created to study disease mechanisms, with enormous therapeutic potential.

Despite the progress in genome engineering, the CRISPR gene editing process consists of major sequential and potentially stressful events, such as clonal expansion, FACS enrichment, drug selection, manual colony picking or stressful single-cell dissociation. By triggering selective pressures on cells, these procedures could favour the generation and selection of genetically abnormal hPSCs, and consequently render these cells unsuitable for further use.

Therefore, efficient and rapid screening of CRISPR-modified hPSCs is essential before their use for research purposes or clinical applications.

Discover the test and request a quote

Latest news

discover and share

The discovery and recent advances in the CRISPR/Cas9 gene-editing technology have profoundly reshaped the field of genome engineering and allowed the generation of a wide range of mutant cell lines at an unprecedented rate. However, CRISPR/Cas9 gene editing in hPSCs can also pose a threat to the overall genomic integrity. Why? To know more, have a look at our July newsletter!

Stem cells are the heart of many of tomorrow personalized therapies. Join us at the most comprehensive meeting in stem cell science, the ISSCR 2021. It will take place virtually from 21 to 26 June 2021. Discover our services for your stem cell research projects and meet us at our booth during this virtual event! We are eager to answer any questions you might have.

Stay informed

Subscribe to our newsletter

Subscribe to our newsletter
By subscribing, you authorize Stem Genomics to register your email address. We will only use your email address to send you our newsletter. We respect your data and follow GDPR. Please see our privacy policy for further details.