CRISPR/Cas9: a threat to the overall genomic integrity of PSCs

CRISPR/Cas9 gene editing: a threat to genomic integrity

The discovery and recent advances in the CRISPR/Cas9 gene-editing technology have profoundly reshaped the field of genome engineering and allowed the generation of a wide range of mutant cell lines at an unprecedented rate.
However, CRISPR/Cas9 gene editing in hPSCs can also pose a threat to the overall genomic integrity.
Why? To know more, have a look at our July newsletter!

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The workflow for PSC genetic integrity quality control recommended by Stem Genomics

PSC workflow: Introducing practical guidelines for regular in-process testing of PSC lines

It is widely recognised that Pluripotent Stem Cells (PSCs) need close monitoring to ensure their genomic integrity throughout prolonged cultures. However, the challenge remains in putting the theory into practice: How frequently should PSCs be tested? And which steps are critical in the process? In this article, we provide specific guidelines for the genomic integrity characterisation of PSCs. They are based on recognised publications and on Stem Genomics’ experience in PSC quality testing.

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